一、团队简介

本团队主要针对一些临床多见但长期无特效药治疗的心脏疾病，如心肌肥厚，扩张型心肌病，心脏衰老，肿瘤心脏病学等，进行相关疾病发病机制的研究以及特效药物的高通量筛选，最终致力于临床转化。

二、团队负责人简介

孙宁：男，教授，博士生导师，必威副院长。入选第四批国家级引进人才（青年），国家自然科学基金-优秀青年科学基金及上海市“优秀学术带头人计划”。在复旦工作期间获得复旦大学十佳研究生导师称号。获得第七届全国大学生基础医学创新研究暨实验设计论坛总决赛优秀指导教师。

2000年获复旦大学必威临床医学专业学士学位；2008年获美国爱荷华州立大学分子细胞发育生物学系博士学位。2008年-2013年间在斯坦福大学必威医学系进行博士后工作；2013年-2021年间在复旦大学基础必威任研究员，生理与病理生理学系副主任；2022年起任必威及江南大学附属医院教授。

孙宁教授长期从事多能干细胞生物学，分子心脏医学和心血管疾病机制及器官间对话的分子机制等中西医结合研究。在斯坦福大学留学期间率先建立了脂肪干细胞重编程为诱导多能干细胞的新方法(PNAS, 2009,引用: 610次)。首次建立了人类家族遗传性扩张型心肌病诱导多能干细胞的模型并进行了疾病新机制的研究(Science Translational Medicine, 2012，引用: 580次)。回国后建立了人类诱导多能干细胞分化来源的心室肌细胞的纯化新技术，制备了可用于移植的人造人类心室肌组织，拓展了生物新材料治疗人类心肌梗塞的应用研究(Biomaterials 2016；Nature Biomedical Engineering 2019; Acta Biomaterialia 2019)；开拓了家族遗传性心肌病基因治疗的临床前转化研究等（Nature Communications, 2020; Protein Cell, 2020, 2021; Ebiomedicine ,2021; Acta Pharmacological Sinica, 2021; JMCC, 2018）。已发表包括Nature Biomedical Engineering, Science Translational Medicine, Nature Methods, Cell Stem Cell, Nature Communications, Biomaterials, Protein Cell等杂志在内的SCI论文60余篇，论文被引用3000余次，申请美国专利两项，中国专利三项，授权2项。现任中国病理生理学会理事,心血管专委会青年委员、中国生理学会心血管专委会委员、中国微循环协会理事、上海市病理生理学会理事、上海市生理学会理事。

邮箱：sunning@jiangnan.edu.cn

三、团队成员简介

吴可嘉：男，副教授。2020年获澳门大学中华医药研究院生物医药博士学位。多年来一直从事基于虚拟筛选技术的天然产物药物发现及其机制研究。在药物高通量筛选平台建设，诊疗一体化技术开发及心血管疾病机制研究等发方面有较强的研究成果和研究实力。近5年，主持国家自然科学基金项目1项，横向课题1项，申报国家发明专利1项,已在Angewandte Chemie International Edition, TrAC Trends in Analytical Chemistry, ACS sensors, European Journal of Medicinal Chemistry等期刊上发表SCI论文20余篇，其中第一（含并列）作者论文16篇。现任江苏省病理生理学会青年委员会青年委员。

邮箱：kj-wu@outlook.com

邵晨雯：女，副教授。2021年获南京大学生物学博士学位。研究方向为心血管疾病的中西医防治机制；探针开发与高通量药物可视化筛选。近年来，基于氧化应激中活性标志物的诊断与调控，结合高通量成像，建立了候选药物快速筛选与样本原位即时检测平台。以第一（含并列）及通讯作者身份在美国科学院院刊PNAS、Cell Press细胞出版社期刊Cell Chemical Biology和STAR Protocols（约稿）、Advanced Science（并列）等国际权威期刊上发表10篇代表性论文。现任江苏省病理生理学会青年委员会青年委员。

邮箱：shaochenwen@jiangnan.edu.cn

叶超：男，讲师。2022年6月获得南京医科大学基础医学生理学专业博士学位。同年7月入职必威。博士期间一直从事心血管疾病尤其是高血压血管重构的发生机制与靶点干预等方面的研究。近5年主持完成江苏省研究生科研创新计划1项。近5年，以第一/共一作者发表SCI研究论文6篇，3篇为一区TOP期刊，单篇最高影响因子为11.6，累计影响因子大于40。曾获得博士研究生国家奖学金、扬子江药业奖学金、南京医科大学“优秀毕业生”等荣誉称号。现任江苏省病理生理学会青年委员会青年委员。

邮箱：yechao@jiangnan.edu.cn

陈琦：女，讲师。2018年获得南京中医药大学中药学和英国女王大学天然药物开发的硕士双学位。2022年获得南京中医药大学中药学博士学位。多年来一直从事中药及中药复方抗心血管疾病的药效评价及相关机制研究。近5年，以第一作者发表6篇SCI论文，累计IF=26.03（2篇为二区），发表中文核心1篇，主持江苏省研究生创新项目1项。

邮箱：qichenjn@sina.com

四、团队代表性科研项目

五、团队代表性科研成果

（一）主要论文

1. Liang, Q., Wang, S., Zhou, X., Li, Y., Xing, S., Sha, Y., Yang, F., Huang, W., Liu, N., Li, Z., Chen, Y., Xu, Y., Zhu, P., Lan, F., &Sun, N. (2022). Essential role of MESP1-RING1A complex in cardiac differentiation. Developmental cell, 57(22), 2533–2549.e7.

2. Zheng, Y., Sun, W., Wang, Z., Liu, J., Shan, C., He, C., Li, B., Hu, X., Zhu, W., Liu, L., Lan, F., Jiang, C., Zhao, C., Li, X., &Sun, N. (2022). Activation of Pancreatic Acinar FXR Protects against Pancreatitis via Osgin1-Mediated Restoration of Efficient Autophagy. Research (Washington, D.C.), 2022, 9784081.

3. Xu, D., Ma, R., Ju, Y., Song, X., Niu, B., Hong, W., Wang, R., Yang, Q., Zhao, Z., Zhang, Y., Zheng, Y., Bai, Q., Lv, M.,Sun, N.*, & Li, X.* (2022). Cholesterol sulfate alleviates ulcerative colitis by promoting cholesterol biosynthesis in colonic epithelial cells. Nature communications, 13(1), 4428.

4. Xu, L., Lin, J., Liu, Y., Hua, B., Cheng, Q., Lin, C., Yan, Z., Wang, Y.,Sun, N.*, Qian, R.*, & Lu, C*. (2022). CLOCK regulates Drp1 mRNA stability and mitochondrial homeostasis by interacting with PUF60. Cell reports, 39(2), 110635.

5. Cui, B., Zheng, Y., Gao, X., Zhang, L., Li, B., Chen, J., Zhou, X., Cai, M., Sun, W., Zhang, Y., Chang, K., Xu, J., Zhu, F., Luo, Y.*, Sun, T.*, Qian, J.*, &Sun, N.*(2022). Therapeutic application of chick early amniotic fluid: effective rescue of acute myocardial ischemic injury by intravenous administration. Cell regeneration (London, England), 11(1), 9.

6. Li, B., Zhan, Y., Liang, Q., Xu, C., Zhou, X., Cai, H., Zheng, Y., Guo, Y., Wang, L., Qiu, W., Cui, B., Lu, C., Qian, R., Zhou, P., Chen, H., Liu, Y., Chen, S., Li, X., &Sun, N.*(2022). Isogenic human pluripotent stem cell disease models reveal ABRA deficiency underlies cTnT mutation-induced familial dilated cardiomyopathy. Protein & cell, 13(1), 65–71.

7. Huang, J., Liu, Y., Chen, J. X., Lu, X. Y., Zhu, W. J., Qin, L., Xun, Z. X., Zheng, Q. Y., Li, E. M.,Sun, N.*, Xu, C.*, & Chen, H. Y.* (2022). Harmine is an effective therapeutic small molecule for the treatment of cardiac hypertrophy. Acta pharmacologica Sinica, 43(1), 50–63.

8. Shao, C., Liu, Y., Chen, Z., Qin, Y., Wang, X., Wang, X., Yan, C., Zhu, H. L.*, Zhao, J.*, & Qian, Y.*(2022). 3D two-photon brain imaging reveals dihydroartemisinin exerts antiepileptic effects by modulating iron homeostasis. Cell chemical biology, 29(1), 43–56.e12.

9. Shao, C., Chen, Z. P., Yan, C.*, & Qian, Y.* (2022). 3D tracking of ferrous iron in the epileptic mouse brain and screening of iron homeostasis regulators with a two-photon fluorescent probe. STAR protocols, 3(3), 101522.

10. Shao, C., Wu, J., Han, S., Liu, Y., Su, Z., Zhu, H. L.*, Liu, H. K.*, & Qian, Y.* (2022). Biotinylated curcumin as a novel chemosensitizer enhances naphthalimide-induced autophagic cell death in breast cancer cells. European journal of medicinal chemistry, 228, 114029.

11. Ye, C., Zheng, F., Xu, T., Wu, N., Tong, Y., Xiong, X. Q., Zhou, Y. B., Wang, J. J., Chen, Q., Li, Y. H., Zhu, G. Q.*, & Han, Y.* (2022). Norepinephrine acting on adventitial fibroblasts stimulates vascular smooth muscle cell proliferation via promoting small extracellular vesicle release. Theranostics, 12(10), 4718–4733.

12. Ye, C., Geng, Z., Zhang, L. L., Zheng, F., Zhou, Y. B., Zhu, G. Q., & Xiong, X. Q.* (2022). Chronic infusion of ELABELA alleviates vascular remodeling in spontaneously hypertensive rats via anti-inflammatory, anti-oxidative and anti-proliferative effects. Acta pharmacologica Sinica, 10.1038/s41401-022-00875-w.

13. Ye, C., Zheng, F., Wu, N., Zhu, G. Q.*, & Li, X. Z.* (2022). Extracellular vesicles in vascular remodeling. Acta pharmacologica Sinica, 43(9), 2191–2201.

14. Li, X., Gao, F., Wang, X., Liang, Q., Bai, A., Liu, Z., Chen, X., Li, E., Chen, S., Lu, C., Qian, R.,Sun, N.*, Liang, P.*, & Xu, C.* (2021). E2A ablation enhances proportion of nodal-like cardiomyocytes in cardiac-specific differentiation of human embryonic stem cells. EBioMedicine, 71, 103575.

15. Li, B., Guo, Y., Zhan, Y., Zhou, X., Li, Y., Zhao, C.,Sun, N.*, Xu, C.*, & Liang, Q.* (2021). Cardiac Overexpression of XIN Prevents Dilated Cardiomyopathy Caused by TNNT2 ΔK210 Mutation. Frontiers in cell and developmental biology, 9, 691749.

16. Chen, X., Liu, Y., Xu, C., Ba, L., Liu, Z., Li, X., Huang, J., Simpson, E., Gao, H., Cao, D., Sheng, W., Qi, H., Ji, H., Sanderson, M., Cai, C. L., Li, X., Yang, L., Na, J., Yamamura, K., Liu, Y., …Sun, N.*(2021). QKI is a critical pre-mRNA alternative splicing regulator of cardiac myofibrillogenesis and contractile function. Nature communications, 12(1), 89.

17. Shao, C., Hedberg, C., & Qian, Y.* (2021). In Vivo Imaging of the Macrophage Migration Inhibitory Factor in Liver Cancer with an Activity-Based Probe. Analytical chemistry, 93(4), 2152–2159.

18. Wu, K. J., Wu, C., Fang, M., Ding, B., Liu, P., Zhou, M., Gong, Z.*, Ma, D. L.*, & Leung, C. H.* (2021) Application of metal–organic framework for the adsorption and detection of food contamination. TrAC Trends in Analytical Chemistry, 143, 116384.

19. Wu, K. J., Wu, C., Chen, F., Cheng, S. S., Ma, D. L.*, & Leung, C. H.* (2021). Time-Resolved Luminescent High-Throughput Screening Platform for Lysosomotropic Compounds in Living Cells. ACS sensors, 6(1), 166–174.

20. Ye, C., Tong, Y., Wu, N., Wan, G. W., Zheng, F., Chen, J. Y., Lei, J. Z., Zhou, H., Chen, A. D., Wang, J. J., Chen, Q., Li, Y. H., Kang, Y. M., & Zhu, G. Q.* (2021). Inhibition of miR-135a-5p attenuates vascular smooth muscle cell proliferation and vascular remodeling in hypertensive rats. Acta pharmacologica Sinica, 42(11), 1798–1807.

21. Ye, C., Zheng, F., Wang, J. X., Wang, X. L., Chen, Q., Li, Y. H., Kang, Y. M., & Zhu, G. Q.* (2021). Dysregulation of the Excitatory Renal Reflex in the Sympathetic Activation of Spontaneously Hypertensive Rat. Frontiers in physiology, 12, 673950.

22. Chen, Q., Qi, X., Zhang, W., Zhang, Y., Bi, Y., Meng, Q., Bian, H.*, & Li, Y.* (2021). Catalpol Inhibits Macrophage Polarization and Prevents Postmenopausal Atherosclerosis Through Regulating Estrogen Receptor Alpha. Frontiers in pharmacology, 12, 655081.

23. Chen, Q., Qi, X., Fu, Y., Ji, T., Chao, Y., Li, J., Meng, Q., Bian, H., & Li, Y.* (2021). Liuwei Dihuang formula protect endothelial cells from apoptosis by up-regulating expression of estrogen receptor-α. Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan, 41(2), 227–235.

24. Wang, S., Chen, H., Zheng, Y., Li, Z., Cui, B., Zhao, P., Zheng, J., Lu, R.*, &Sun, N.*(2020). Transcriptomics- and metabolomics-based integration analyses revealed the potential pharmacological effects and functional pattern of in vivo Radix Paeoniae Alba administration. Chinese medicine, 15, 52.

25. Li, E., Li, X., Huang, J., Xu, C., Liang, Q., Ren, K., Bai, A., Lu, C.*, Qian, R.*, &Sun, N.*(2020). BMAL1 regulates mitochondrial fission and mitophagy through mitochondrial protein BNIP3 and is critical in the development of dilated cardiomyopathy. Protein & cell, 11(9), 661–679.

26. Zheng, Y., Cui, B., Sun, W., Wang, S., Huang, X., Gao, H., Gao, F., Cheng, Q., Lu, L., An, Y., Li, X.*, & Sun, N.* (2020). Potential Crosstalk between Liver and Extra-liver Organs in Mouse Models of Acute Liver Injury. International journal of biological sciences, 16(7), 1166–1179.

27. Shao, C., Yuan, J., Liu, Y., Qin, Y., Wang, X., Gu, J., Chen, G., Zhang, B., Liu, H. K., Zhao, J.*, Zhu, H. L.(, & Qian, Y.( (2020). Epileptic brain fluorescent imaging reveals apigenin can relieve the myeloperoxidase-mediated oxidative stress and inhibit ferroptosis. Proceedings of the National Academy of Sciences of the United States of America, 117(19), 10155–10164.

28. Wu, K. J., Wang, W., Wang, H. D., Leung, C. H.*, & Ma, D. L.* (2020). Interfering with S100B-effector protein interactions for cancer therapy. Drug discovery today, 25(9), 1754–1761.

29. Wang, W.,Wu, K. J.(Co-first Author), Vellaisamy, K., Leung, C. H.*, & Ma, D. L.* (2020). Peptide-Conjugated Long-Lived Theranostic Imaging for Targeting GRPr in Cancer and Immune Cells. Angewandte Chemie (International ed. in English), 59(41), 17897–17902.

30. Wu, C.,Wu, K. J. (Co-first Author), Liu, J. B., Wang, W., Leung, C. H.*, & Ma, D. L.* (2020). Structure-guided discovery of a luminescent theranostic toolkit for living cancer cells and the imaging behavior effect. Chemical science, 11(42), 11404–11412.

31. Ye, C., Qiu, Y., Zhang, F., Chen, A. D., Zhou, H., Wang, J. J., Chen, Q., Li, Y. H., Kang, Y. M., & Zhu, G. Q.* (2020). Chemical Stimulation of Renal Tissue Induces Sympathetic Activation and a Pressor Response via the Paraventricular Nucleus in Rats. Neuroscience bulletin, 36(2), 143–152.

32. Geng, Z.,Ye, C. (Co-first Author), Tong, Y., Zhang, F., Zhou, Y. B., & Xiong, X. Q.* (2020). Exacerbated pressor and sympathoexcitatory effects of central Elabela in spontaneously hypertensive rats. American journal of physiology. Heart and circulatory physiology, 318(1), H124–H134.

33. Chen, Q., Zhang, D., Bi, Y., Zhang, W., Zhang, Y., Meng, Q., Li, Y.*, & Bian, H.* (2020). The protective effects of liguzinediol on congestive heart failure induced by myocardial infarction and its relative mechanism. Chinese medicine, 15, 63.

34. Chen, Q., Chao, Y., Zhang, W., Zhang, Y., Bi, Y., Fu, Y., Cai, D., Meng, Q., Li, Y., & Bian, H.* (2020). Activation of estrogen receptor α (ERα) is required for Alisol B23-acetate to prevent post-menopausal atherosclerosis and reduced lipid accumulation. Life sciences, 258, 118030.

35. Chen, Q.*, Zhang, Y., Meng, Q., Wang, S., Yu, X., Cai, D., Cheng, P., Li, Y., & Bian, H.* (2020). Liuwei Dihuang prevents postmenopausal atherosclerosis and endothelial cell apoptosis via inhibiting DNMT1-medicated ERα methylation. Journal of ethnopharmacology, 252, 112531.

36. Lin, X., Liu, Y., Bai, A., Cai, H., Bai, Y., Jiang, W., Yang, H., Wang, X., Yang, L.*,Sun, N.*, & Gao, H.* (2019). A viscoelastic adhesive epicardial patch for treating myocardial infarction. Nature biomedical engineering, 3(8), 632–643.获同行评价 (Editorial Commentary)

37. Cui, B., Zheng, Y., Zhou, X., Zhu, J., Zhuang, J., Liang, Q., Xu, C., Sheng, W., Huang, G., Luan, L., &Sun, N.*(2019). Repair of Adult Mammalian Heart After Damages by Oral Intake of Gu Ben Pei Yuan San. Frontiers in physiology, 10, 607.

38. Yang, H., Wei, L., Liu, C., Zhong, W., Li, B., Chen, Y., Han, R., Zhuang, J., Qu, J., Tao, H., Chen, H., Xu, C., Liang, Q., Lu, C., Qian, R., Chen, S., Wang, W.*, &Sun, N.*(2019). Engineering human ventricular heart tissue based on macroporous iron oxide scaffolds. Acta biomaterialia, 88, 540–553.

39. Hu, J. S.,Shao, C.(Co-first Author),, Wang, X., Di, X., Xue, X., Su, Z., Zhao, J., Zhu, H. L.*, Liu, H. K.*, & Qian, Y.* (2019). Imaging Dynamic Peroxynitrite Fluxes in Epileptic Brains with a Near-Infrared Fluorescent Probe. Advanced science (Weinheim, Baden-Wurttemberg, Germany), 6(15), 1900341.

40. Cui, B., Zheng, Y., Sun, L., Shi, T., Shi, Z., Wang, L., Huang, G.*, &Sun, N.*(2018). Heart Regeneration in Adult Mammals after Myocardial Damage. Acta Cardiologica Sinica, 34(2), 115–123.

41. Zhan, Y., Sun, X., Li, B., Cai, H., Xu, C., Liang, Q., Lu, C., Qian, R., Chen, S., Yin, L., Sheng, W., Huang, G., Sun, A.*, Ge, J.*, &Sun, N.*(2018). Establishment of a PRKAG2 cardiac syndrome disease model and mechanism study using human induced pluripotent stem cells. Journal of molecular and cellular cardiology, 117, 49–61.

42. Chen, Q., Cheng, P., Ma, C., Xi, X., Wang, L., Zhou, M., Bian, H.*, & Chen, T. (2018). Evaluating the Bioactivity of a Novel Broad-Spectrum Antimicrobial Peptide Brevinin-1GHa from the Frog Skin Secretion of Hylarana guentheri and Its Analogues. Toxins, 10(10), 413.

43. Wu, K. J., Zhong, H. J., Li, G., Liu, C., Wang, H. D., Ma, D. L.*, & Leung, C. H.* (2018). Structure-based identification of a NEDD8-activating enzyme inhibitor via drug repurposing. European journal of medicinal chemistry, 143, 1021–1027.

44. Li, B., Yang, H., Wang, X., Zhan, Y., Sheng, W., Cai, H., Xin, H., Liang, Q., Zhou, P., Lu, C., Qian, R., Chen, S., Yang, P., Zhang, J., Shou, W., Huang, G.*, Liang, P.*, &Sun, N.*(2017). Engineering human ventricular heart muscles based on a highly efficient system for purification of human pluripotent stem cell-derived ventricular cardiomyocytes. Stem cell research & therapy, 8(1), 202.

45. Wang, Q., Yang, H., Bai, A., Jiang, W., Li, X., Wang, X., Mao, Y., Lu, C., Qian, R., Guo, F., Ding, T., Chen, H., Chen, S., Zhang, J.*, Liu, C.*, &Sun, N.*(2016). Functional engineered human cardiac patches prepared from nature's platform improve heart function after acute myocardial infarction. Biomaterials, 105, 52–65.

46. Lu, C., Yang, Y., Zhao, R., Hua, B., Xu, C., Yan, Z.,Sun, N.*, & Qian, R.* (2016). Role of circadian gene Clock during differentiation of mouse pluripotent stem cells. Protein & cell, 7(11), 820–832. 32.封面文章(Cover Article)

47. Liang, Q., Xu, C., Chen, X., Li, X., Lu, C., Zhou, P., Yin, L., Qian, R., Chen, S., Ling, Z., &Sun, N.*(2015). The roles of Mesp family proteins: functional diversity and redundancy in differentiation of pluripotent stem cells and mammalian mesodermal development. Protein & cell, 6(8), 553–561.

48. Zhao, Q., Cai, H., Zhan, Y., Li, B., Hu, S., &Sun, N.*(2014). Applications of human-induced pluripotent stem cells in the investigation of inherited cardiomyopathy. International journal of cardiology, 177(2), 604–606.

49. Sun, N., Yazawa, M., Liu, J., Han, L., Sanchez-Freire, V., Abilez, O. J., Navarrete, E. G., Hu, S., Wang, L., Lee, A., Pavlovic, A., Lin, S., Chen, R., Hajjar, R. J., Snyder, M. P., Dolmetsch, R. E., Butte, M. J., Ashley, E. A., Longaker, M. T., Robbins, R. C., … Wu, J. C.* (2012). Patient-specific induced pluripotent stem cells as a model for familial dilated cardiomyopathy. Science translational medicine, 4(130), 130ra47.封面文章(Cover Article)

50. Liu, J.,Sun, N.(Co-first Author), Bruce, M. A., Wu, J. C., & Butte, M. J.* (2012). Atomic force mechanobiology of pluripotent stem cell-derived cardiomyocytes. PloS one, 7(5), e37559.

51. Sun, N., Longaker, M. T., & Wu, J. C.* (2010). Human iPS cell-based therapy: considerations before clinical applications. Cell cycle (Georgetown, Tex.), 9(5), 880–885.

52. Sun, N., Huiatt, T. W., Paulin, D., Li, Z., & Robson, R. M.* (2010). Synemin interacts with the LIM domain protein zyxin and is essential for cell adhesion and migration. Experimental cell research, 316(3), 491–505.重点突出文章(Highlighted Article)

53. Sun, N., Lee, A., & Wu, J. C.* (2009). Long term non-invasive imaging of embryonic stem cells using reporter genes. Nature protocols, 4(8), 1192–1201.

54. Sun, N., Panetta, N. J., Gupta, D. M., Wilson, K. D., Lee, A., Jia, F., Hu, S., Cherry, A. M., Robbins, R. C., Longaker, M. T., & Wu, J. C.* (2009). Feeder-free derivation of induced pluripotent stem cells from adult human adipose stem cells. Proceedings of the National Academy of Sciences of the United States of America, 106(37), 15720–15725.

55. Sun, N., Critchley, D. R., Paulin, D., Li, Z., & Robson, R. M.* (2008). Human alpha-synemin interacts directly with vinculin and metavinculin. The Biochemical journal, 409(3), 657–667.获同行评价(Editorial Commentary)

56. Sun, N., Critchley, D. R., Paulin, D., Li, Z., & Robson, R. M.* (2008). Identification of a repeated domain within mammalian alpha-synemin that interacts directly with talin. Experimental cell research, 314(8), 1839–1849.

（二）发明专利

1、一种弹性导电胶体、制备方法及应用，专利授权号：ZL 201510004341.0

2、人类多能干细胞来源的人类心室肌细胞的筛选于制备方法，专利申请号：201611271273.5;公开号：CN108265029A

3、一种治疗心力衰竭的复方制剂，专利申请号：201810862112.6；公开号：CN110772551A

4、ABRA在制备改善扩张型心肌病功能药物中的用途，专利申请号：20190241255.X；公开号：CN111743911A

（三）获奖情况

1、2021年第七届全国大学生基础医学创新研究暨实验设计论坛优秀指导教师

2、2021年度复旦大学十佳“三好”研究生导学团队

3、2020年度上海市科学技术奖科技进步奖一等奖，《免疫性疾病的间充质干细胞关键技术的创新与临床应用》（赵春华、白雪源、吴际、曹翠红、孙宁、陈思锋等）

4、2017年入选上海市科委“优秀学术带头人计划”

5、2014年入选国家自然科学基金“优秀青年科学基金”

6、2012年-2014年获美国心脏协会（AHA）博士后基金奖励

7、2010年-2012年获橡树基金会（Oak Foundation）心血管研究基金奖励

六、团队合影